Amusingly, I played on a non-canon WoD themed muck, a guy named Hobbes, a nine-lived tigerwere. Magic using, related to the Fae (they used to hunt Elves before they traded immortality for nine lives as humans), this guy was part Were, part Mage, and part Fae, with drawbacks consistent with each ... and a lot of fun. Borderline twinkish - I can play high-powered without getting too out of hand - but people seemed to find him all sorts of fun. He ended up becoming an agent of Bureau 13.
Such a thing I'm not like to do again.